antibiotics | HISTAMINE

SEAFOOD & Others

ProGnosis Biotech is a leading innovator in the provision of testing solutions for the seafood, meat, and honey sectors. We specialize in the development and distribution of a diverse array of products designed for the precise detection of contaminants such as histamine and antibiotic residues in food commodities, including chloramphenicol, and tetracyclines.

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Histamine, a naturally occurring compound, is often present in certain types of fish and seafood. To ensure the safety and quality of these products, we offer ELISA and Symmetric lateral flow assays, which facilitate rapid and accurate analysis. Our histamine detection kits have been validated by the esteemed ILVO – Institute for Agriculture, Fisheries, and Food Research.y using Bio-Shield ELISA and Symmetric mycotoxin kits, it is possible to identify and control the presence of mycotoxins in grains, and to ensure that they meet regulatory standards and do not pose a risk to human and animal health.

Antibiotics are used in farming, aquacultures and apicultures as a method of treating bacterial infections and preventing the spread of disease in crowded conditions, which are common occurrence. Prognosis Biotech offers solutions for detecting common antibiotics, such as Chloramphenicol and Tetracycline residues, with its ELISA and Lateral Flow testing solutions.



The use of antibiotics is a common practice in farming, aquaculture and apiculture in order to treat or prevent diseases and keep the animals healthy. After the treatment with antibiotics, trace amounts of them remain biologically active and unaltered in the animals’ tissues and their byproducts.

Consuming food with antibiotic residues poses significant risk, as they may cause allergic reactions, carcinogenicity, mutagenicity, hepatoxicity and lead to antibiotic resistance. In order to avoid these, and many more, negative impacts, food commodities should adhere to the standards set by each country by being tested. Some of the most common and closely monitored antibiotics are Chloramphenicol and Tetracyclines.

Chloramphenicol, a broad-spectrum widely used antibiotic in veterinary medicine, poses potential health risks to consumers if present in food products, as it is a recognized carcinogen and can lead to a variety of disorders, including bone marrow depression, aplastic anemia, and other blood-related conditions. As such, its usage is strictly regulated. ProGnosis Biotech provides a reliable detection solution for chloramphenicol in meat, seafood, dairy products, and honey through our ELISA method.

Tetracyclines, a group of broad-spectrum antibiotics, may find their way into honey if beekeepers use them to manage diseases in bee colonies. These antibiotics can accumulate within beehives and subsequently migrate into the honey, leading to potential product contamination. Consumption of honey contaminated with tetracycline residues can pose significant health risks, including carcinogenicity. To address this, ProGnosis Biotech offers a lateral flow test specifically designed for the detection of tetracyclines in honey.

In essence, ProGnosis Biotech is committed to ensuring the safety and quality of food products through our innovative detection solutions.



Histamine is a heterocyclic primary amine and is the by-product of the decarboxylation of the amino acid L-histidine by the enzyme histidine decarboxylase. The latter is produced by certain bacteria that can be found in seafood. 

The most common fish species that tend to accommodate Histamine belongs to the scombroid family of fish (tuna, mahi mahi, marlin, bluefish, sardines, anchovy, bonito, herring, and mackerel). After the fish are harvested the bacterial growth results in increasing histidine decarboxylase amounts which in turn induces Histamine production. 

High levels of Histamine may cause scombroid poisoning in humans which consists of various symptoms, such as rash, nausea, vomiting, diarrhea, hypotension, heart palpitations, and muscle weakness. Most controlling government agencies worldwide have regulations regarding the amount of Histamine allowable in fish and fish products. 

Histamine levels in fish of good quality are usually below 10 ppm. Histamine values between 50 and 200 ppm are acceptable depending on the fish species and the country. The accurate and rapid determination of Histamine presence in commodities is quite important.